Thermo Fisher tools uncover 2,762 biological links in Singapore

Thermo Fisher Scientific announced on October 5, 2026, that its collaboration with Precision Health Research, Singapore (PRECISE) and Nanyang Technological University, Singapore (NTU Singapore) identified 2,762 previously unreported associations between genetic variations and protein levels. The initial data were presented at the Human Proteome Organization (HUPO) 2026 World Congress.

The findings stem from the analysis of the first 10,000 participant samples in the PRECISE-SG100K study, which has recruited more than 100,000 individuals from Singapore's Asian population. Researchers measured about 8,800 protein groups and identified over 4,200 proteins linked to nearby genetic differences. More than 2,500 of those associations had not been reported across 12 reference studies used for comparison.

The study deployed Thermo Fisher's Orbitrap Astral mass spectrometry platform alongside its Olink Proximity Extension Assay technology and Seer's Proteograph Product Suite. Researchers also linked measured proteins to 71 health-related traits, confirming known relationships such as the link between sclerostin and bone mineral density in osteoporosis research.

The research agreement was originally formed in April. Thermo Fisher Scientific, which generates annual revenue of over $45 billion, noted that the combined workflow allows researchers to achieve analytical depth while processing large population-scale sample volumes for biomarker and drug target discovery.